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As evidence-of-basic principle that manipulation of Period I metabolism would change the in vivo effects from the SCBs, hypothermic effects of 3 mg/kg JWH-018 or 5F-AB-PINACA ended up identified making use of radiotelemetry during the presence or absence of the worldwide CYP450 inhibitor 1-ABT in mice (Encyclopaedia Britannica's editors oversee sub